7/6/2023 0 Comments Scorpid by Adam ResslerFinally, we present our perspectives on two specific treatments pertinent to patient outcomes: metronidazole administration and surgery. Next, we highlight clinical factors including renal dysfunction, aging, blood biomarkers, level of care, and chronic illnesses that can affect severe CDI diagnosis and outcome. Furthermore, we identify associations between host immune factors and CDI outcomes in both animal models and human studies. difficile genetics and virulence factors in the molecular epidemiology of CDI, and the utility of early biomarkers in predicting the clinical trajectory of patients at risk of developing severe CDI. In this narrative review, we discuss the implications of C. difficile microbial factors, host immunologic signatures, and clinical features that are associated with adverse outcomes of severe CDI. It is therefore imperative to better characterize the intricate interplay between C. In the United States, Clostridioides difficile infection (CDI) is the leading cause of healthcare-associated infection, affecting nearly half a million people and resulting in more than 20,000 in-hospital deaths every year.
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